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How it Works

ENDOCUFF VISION™ is a device attached to the distal end of a colonoscope, designed to maintain and maximize the viewable mucosa during endoscopic therapy by manipulating colonic folds.

A single row of flexible arms evert and flatten folds to provide an enhanced view of the entire colon and to decrease the polyp miss rate. 8

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NICE Guidance

The National Institute for Health and Care Excellence (NICE) has produced guidance on ENDOCUFF VISION™ for assisting visualization during colonoscopy in the NHS in England. 5,17-21

Adenoma Detection Rate
Increases the adenoma detection rate by up to 11% (result of meta-analysis) — for every 1,000 patients screened, it is estimated that up to 110 patients with an adenoma could have been additionally identified using the ENDOCUFF technology 15

A 1% Increase in ADR Leads To:

  • 3% decrease in the risk of interval cancer. 5
  • 5% decrease in the risk of a fatal interval colorectal cancer. 5

Widely tested in 12 randomized controlled trials with more than 8,000 patients and 140 colonoscopists, plus experts and endoscopists 15

ENDOCUFF VISION™ shows no adverse or serious adverse events when tested in over 800 patients by 70 endoscopists 11

ENDOCUFF VISION - Meta-Analysis of Randomized Controlled Trials

Causes for Concern with Unseen Adenomas and Polyps:

  • 24% of adenomas are missed with standard colonoscopy. 7
  • 40% of polyps go undetected. 8

ENDOCUFF VISION™ maximizes visualization during a colonoscopy, decreasing the overall polyp miss rate. 10

Download Study Summaries

Teaching Video - ENDOCUFF VISION™ - Tips & Tricks From the Experts

Watch Prof Brian Saunders, Consultant Gastroenterologist at St. Mark's Hospital (London) and Dr. Med Andrea Pace, Head Doctor of the Gastroenterology Department at the Friedrich-Ebert-Krankenhaus (Neumünster), share insights and valuable experience on how to optimize endoscope performance with ENDOCUFF VISION®, including best practices for intubation, withdrawal, and Endocuff-assisted polypectomy.

EndoTherapy Catalog

Article codes, specifications and more information on ENDOCUFF VISION™, as well as the complete portfolio of ET devices, are available here.

Enter the EndoTherapy world now.


  1. 1.The difficult colonoscopy Can J Gastroenterol. 2007;21(8):487-490 Witte TN, Enns R.
  2. 2.Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel Am J Gastroenterol. 2012;107(9):1315-1329 Rex DK, Ahnen DJ, Baron JA, et al.
  3. 3.Location of Adenomas Missed by Optical Colonoscopy Ann Intern Med. 2004;141(5):352-359 Pickhardt PJ, Nugent PA, Mysliwiec PA, et al.
  4. 4.Normal Adult Colonic Anatomy in Colonoscopy Video Journal and Encyclopedia of GI Endoscopy. 2013;1(2):390-392. Jayasekeran V, Holt B, Bourke M.
  5. 5.Adenoma Detection Rate and Risk of Colorectal Cancer and Death N Engl J Med. 2014;370(14):1298-1306. Corley DA, Jensen CD, Marks AR, et al.
  6. 6.Variation in Adenoma Detection Rate and the Lifetime Benefits and Cost of Colorectal Cancer Screening: A Microsimulation Model JAMA. 2015;313(23):2349-2358. Meester RG, Doubeni CA, Lansdorp-Vogelaar I, et al.
  7. 7.Impact of a new distal attachment on colonoscopy performance in an academic screening center Gastrointest Endosc, 87(1), 280-287. doi:10.1016/j.gie.2017.04.001 Tsiamoulos Z.P., Misra R., et al.
  8. 8.Endoscopy and polyps — diagnostic and therapeutic advances in management World J Gastroenterol. 2013;19(27):4277-4288. Steele SR, Johnson EK, Champagne B, et al.
  9. 9.Quality indicators for colonoscopy Gastrointest Endosc. 2015;81(1):31-53. Rex DK, Schoenfeld PS, Cohen J, et al.
  10. 10.Higher Adenoma Detection Rates with Endocuff-Assisted Colonoscopy — A Randomised Controlled Multicenter Trial PLoS One, 9(12), e114267. doi:10.1371/journal.pone.0114267 Floer M, Biecker E, Fitzlaff R, et al.
  11. 11.Improved Adenoma Detection with Endocuff Vision: The ADENOMA randomizsed controlled trial Gut, 68(2), 280-288. doi:10.1136/gutjnl-2017-314889 Ngu WS, Bevan R, Tsiamoulos Z.P., et al.
  12. 12.Colonoscopic Polypectomy and Long-Term Prevention of Colorectal-Cancer Deaths Med 2012; 366:687-696 Zauber et al. N Engl J
  13. 13.Protection from colorectal cancer after colonoscopy: a population-based, case-control study Ann Intern Med. 2011 Jan 4;154(1):22-30. Brenner et al.
  14. 14.Risk of colorectal cancer seven years after flexible sigmoidoscopy screening: randomised controlled trial BMJ. 2009 May 29;338:b1846. doi: 10.1136/bmj.b1846. (Bretthauer Group) Hoff et al.
  15. 15.Effect of Endocuff-assisted colonoscopy on adenoma detection rate: meta-analysis of randomised controlled trials Endoscopy, 50(9), 846-860. doi:10.1055/a-0577-3500 Williet, N., Tournier, Q., et al.
  16. 16.Endocuff Vision Reduces Inspection Time Without Decreasing Lesion Detection in a Randomised Colonoscopy Trial Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2019.01.015 Rex, D. K., Slaven, J. E., et al.
  17. 17.Quality Indicators for Colonoscopy and the Risk of Interval Cancer N Engl J Med 2010; 362:1795-1803 Kaminski, M. F., et al. (2010)
  18. 18.ENDOCUFF VISION™ for assisting visualisation during colonoscopy. Medical technologies guidance
  19. 19.Improved adenoma detection with ENDOCUFF VISION™: the ADENOMA randomised controlled trial. Gut 68(2): 280-288. Ngu, W. S., Bevan R., Tsiamoulos Z.P., et al. (2018).
  20. 20.Innovation and Technology Payment 2019/20 NHS England (2019).
  21. 21.2019 “www.bankofengland.co.uk” Bank of England exchange rate, July 19